Article
Resistance-associated substitution and ledipasvir/sofosbuvir therapy in Mongolian chronic hepatitis C patients.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Mar 2020
Hsu Shih-Jer, Enkhzaya Sukhee, Lin You-Yu, Tseng Tai-Chung, Khosbayar Tulgaa, Tsai Cheng-Hsueh, Wang Tzu-San, Enkhtuya Damba, Ivshinkhorol Dogsom, Naranzul Nyamsuren, Jargalsaikhan Badarch, Amarsanaa Jazag, Baatarkhuu Oidov, Kao Jia-Horng
Abstract excerpt
BACKGROUND: Mongolia has the highest prevalence of hepatitis C virus (HCV) infection worldwide. Ledipasvir/sofosbuvir (LDV/SOF) was introduced to Mongolia since 2016 for HCV eradication. It has been reported that HCV resistance-associated substitutions (RASs) would affect the effectiveness of LDV/SOF in western chronic hepatitis C (CHC) patients. We thus investigated the effectiveness of LDV/SOF and the impact of...
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