High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain.

doi:10.1371/journal.pmed.1002961

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain.

PLoS medicine - 1 Oct 2019

Xu Yuanwei, Cancino-Muñoz Irving, Torres-Puente Manuela, Villamayor Luis M, Borrás Rafael, Borrás-Máñez María, Bosque Montserrat, Camarena Juan J, Colomer-Roig Ester, Colomina Javier, Escribano Isabel, Esparcia-Rodríguez Oscar, Gil-Brusola Ana, Gimeno Concepción, Gimeno-Gascón Adelina, Gomila-Sard Bárbara, González-Granda Damiana, Gonzalo-Jiménez Nieves, Guna-Serrano María Remedio, López-Hontangas José Luis, Martín-González Coral, Moreno-Muñoz Rosario, Navarro David, Navarro María, Orta Nieves, Pérez Elvira, Prat Josep, Rodríguez Juan Carlos, Ruiz-García María Montserrat, Vanaclocha Herme, Colijn Caroline, Comas Iñaki

Abstract excerpt

BACKGROUND: Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) identify likely index and missing cases, (2) determine risk factors associated with transmitters,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bayes Theorem

Share to Contact Tracing

Share to Genome, Bacterial

Share to HIV Seropositivity

Share to Mycobacterium tuberculosis

Share to Spain

Share to Tuberculosis, Pulmonary

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 31671150
DOI: 10.1371/journal.pmed.1002961
PMCID: PMC6822721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain.PMID 31671150Read ↗

Population-based sequencing of <i>Mycobacterium tuberculosis</i> reveals how current population dynamics are shaped by past epidemicsSemantic proximity Read ↗

Whole-genome sequencing of Mycobacterium tuberculosis directly from clinical samples for high-resolution genomic epidemiology and drug resistance surveillance: an observational studySemantic proximity Read ↗

Bayesian reconstruction of Mycobacterium tuberculosis transmission networks in a high incidence area over two decades in Malawi reveals associated risk factors and genomic variants.Semantic proximity Read ↗

Comparing Mycobacterium tuberculosis transmission reconstruction models from whole genome sequence data.Semantic proximity Read ↗

Whole-genome sequencing for rapid, reliable and routine investigation of Mycobacterium tuberculosis transmission in local communitiesSemantic proximity Read ↗

Whole genome sequencing of Mycobacterium tuberculosis for detection of recent transmission and tracing outbreaks: A systematic review.Semantic proximity Read ↗

Long-term refined genomic analysis of tuberculosis clusters to distinguish between ongoing transmission, reactivations or diagnostic delays, Almería, Spain, 2003 to 2024.Semantic proximity Read ↗

A whole-genome sequencing study of an X-family tuberculosis outbreak focus on transmission chain along 25 years.Semantic proximity Read ↗

A long-term refined genomic analysis of tuberculosis clusters to discriminate between ongoing transmission, reactivations or diagnostic delaysSemantic proximity Read ↗

An updated method to estimate factors associated with tuberculosis transmission using whole genome sequencing and other additional metadataSemantic proximity Read ↗

Comparing transmission reconstruction models with <i>Mycobacterium tuberculosis</i> whole genome sequence dataSemantic proximity Read ↗

Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.