Article
Clinical management in mixed gonadal dysgenesis with chromosomal mosaicism: Considerations in newborns and adolescents.
Seminars in pediatric surgery - 1 Oct 2019
Weidler Erica M, Pearson Margaret, van Leeuwen Kathleen, Garvey Erin
Abstract excerpt
Individuals born on the spectrum of genetic abnormalities known as mixed gonadal dysgenesis (MGD) have a wide range of anatomical findings and management can be challenging in the newborn and adolescent. Historically, many individuals with MGD have undergone gonadectomy to avert the risk of gonadal malignancy. However, gonadectomy deprives patients of the benefits of their endogenous hormones, potential...
Topics
- Adolescent
- Biopsy
- Decision Making, Shared
- Ethics, Medical
- Fertility
- Gender Identity
- Genetic Predisposition to Disease
- Gonadal Dysgenesis, Mixed
- Hormone Replacement Therapy
- Humans
- Immunohistochemistry
- Infant, Newborn
- Karyotyping
- Laparoscopy