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Article

Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling.

JCI insight - 5 Dec 2019

Sawaya Andrew P, Jozic Ivan, Stone Rivka C, Pastar Irena, Egger Andjela N, Stojadinovic Olivera, Glinos George D, Kirsner Robert S, Tomic-Canic Marjana

Abstract excerpt

Diabetic foot ulcers (DFUs) are a life-threatening disease that often results in lower limb amputations and a shortened life span. Current treatment options are limited and often not efficacious, raising the need for new therapies. To investigate the therapeutic potential of topical statins to restore healing in patients with DFUs, we performed next-generation sequencing on mevastatin-treated primary human...

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Identifiers

PMID: 31661463
DOI: 10.1172/jci.insight.129320
PMCID: PMC6962014

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