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Article

A computational study of the molecular basis of antibiotic resistance in a DXR mutant.

Journal of computer-aided molecular design - 1 Oct 2019

Krebs Fanny S, Esque Jérémy, Stote Roland H

Abstract excerpt

Proteins of the independent mevalonate pathway for isoprenoid biosynthesis are important targets for the development of new antibacterial compounds as this pathway is present in most pathogenic organisms such as Mycobacterium tuberculosis, DPlasmodium falciparum and Escherichia coli, but is not present in mammalian species, including humans. Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an important...

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PMID: 31654265
DOI: 10.1007/s10822-019-00229-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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