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Article

Aberrant epigenetic inactivation of RASSF1A and MGMT gene and genetic mutations of KRAS, cKIT and BRAF in Indian testicular germ cell tumours.

Cancer genetics - 1 Feb 2020

Ahmad Firoz, Surve Purva, Natarajan Sripriya, Patil Ashwini, Pol Smita, Patole Kamlakar, Das Bibhu Ranjan

Abstract excerpt

Testicular germ cell tumor (TGCT) development may involve a series of modification at epigenetic and genetic level which may act synergistically and transform the primordial gonocyte. This study evaluated the frequency and distribution pattern of RASSF1A/MGMT gene methylation and KRAS, BRAF and cKIT gene mutation in Indian TGCT patient, and their correlation with clinicopathological features. Forty-one TGCT...

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Share to DNA Modification Methylases
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

Share to Proto-Oncogene Proteins c-kit

Share to Seminoma

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Identifiers

PMID: 31653608
DOI: 10.1016/j.cancergen.2019.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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