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Article

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

18 Oct 2019

Abstract excerpt

Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse models significantly enhances disease latency and prevents disease maintenance. Loss of CDK8 is associated with pronounced transcriptional changes, whereas inhibiting CDK8 kinase activity has minimal effects. Gene set...

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PMID: 31628323
DOI: 10.1038/s41467-019-12656-x

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