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Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response

10 Oct 2019

Abstract excerpt

Gallbladder cancer (GBC) is the common malignancy of the bile tract system with extremely poor clinical outcomes, owing to its metastatic property and intrinsic resistance to the first-line drugs. Although it is well-established that cholesterol abnormity contributes to gallstone formation, a leading risk factor for GBC, the link of cholesterol homeostasis with GBC has not been investigated. The present study...

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PMID: 31599189
DOI: 10.1080/15384101.2019.1676581

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