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The effect of maternal high-fat/high-sugar diet on offspring oocytes and early embryo development

20 Sept 2019

Abstract excerpt

Observational human data and several lines of animal experimental data indicate that maternal obesity impairs offspring health. Here, we comprehensively tested the model that maternal obesity causes defects in the next three generations of oocytes and embryos. We exposed female F0 mice to a high-fat/high-sugar (HF/HS) diet for 6 weeks before conception until weaning. Sires, F1 offspring and all subsequent...

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PMID: 31588490
DOI: 10.1093/molehr/gaz049

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