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Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice

17 Jun 2020

Abstract excerpt

Maternal obesity can cause reduced oocyte quality and subfertility. Mitochondrial dysfunction plays a central role here, and most often inbred mouse models are used to study these pathways. We hypothesized that the mouse genetic background can influence the impact of high fat diet (HFD)-induced obesity on oocyte quality. We compared the inbred C57BL/6 (B6) and the outbred Swiss strains after feeding a HFD for...

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PMID: 32555236
DOI: 10.1038/s41598-020-66702-6

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