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Development of experimental silicosis in inbred and outbred mice depends on instillation volume

2 Oct 2019

Abstract excerpt

There is considerable variation in methods to induce experimental silicosis with the effects of dose and route of exposure being well documented. However, to what extent the volume of silica suspension alters the dispersion and severity of silicosis has not been adequately investigated. In this study, the optimal volume of a crystalline silica suspension required to obtain uniform distribution and greatest...

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PMID: 31578388
DOI: 10.1038/s41598-019-50725-9

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