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Vitamin D and lipopolysaccharide jointly induce a distinct epigenetic and transcriptional program in human monocytes

28 Jul 2025

Abstract excerpt

Abstract Pathogen-associated molecular patterns such as lipopolysaccharide (LPS) mimic immune responses triggered by bacterial infections. The hormonally active form of vitamin D 3 , 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], supports innate immunity, but its molecular mechanisms remain incompletely understood. We investigated epigenomic and transcriptomic changes in THP-1 monocytes that were either unprimed...

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PMID: 40721933
DOI: 10.1038/s41598-025-10921-2

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