Article
Fluorescence in situ hybridization (FISH) provides estimates of minute and interstitial BAP1, CDKN2A, and NF2 gene deletions in peritoneal mesothelioma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2020
Brich Silvia, Bozzi Fabio, Perrone Federica, Tamborini Elena, Cabras Antonello Domenico, Deraco Marcello, Stacchiotti Silvia, Dagrada Gian Paolo, Pilotti Silvana
Abstract excerpt
The aim of this study was to assess the performance of fluorescence in situ hybridization (FISH) in identifying the copy number profiles of the three key peritoneal mesothelioma tumor suppressor genes BAP1, CDKN2A, and NF2, with particular emphasis on minute homozygous deletions, a copy number abnormality recently unveiled at the 3p21 (BAP1) chromosomal region using high-throughput methods. FISH was performed on...
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