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Article

GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica

30 Sept 2019

Abstract excerpt

BACKGROUND: We previously reported the association between blood-brain barrier (BBB) dysfunction and glucose-regulated protein 78 (GRP 78) autoantibodies in neuromyelitis optica (NMO). OBJECTIVE: We clarify whether the BBB-endothelial cell activation induced by immunoglobulin G (IgG) is associated with the clinical phenotype, disease activity, and markers of BBB disruption. METHODS: We purified serum IgG from 24...

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PMID: 31568704
DOI: 10.1002/acn3.50905

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