Article
Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes.
The Journal of infectious diseases - 8 Oct 2019
Wagner Sarah, Roberson David, Boland Joseph, Kreimer Aimée R, Yeager Meredith, Cullen Michael, Mirabello Lisa, Dunn S Terence, Walker Joan, Zuna Rosemary, Porras Carolina, Cortes Bernal, Sampson Joshua, Herrero Rolando, Rodriguez Ana Cecilia, Quint Wim, Van Doorn Leen-Jan, Hildesheim Allan, Schiffman Mark, Wentzensen Nicolas
Abstract excerpt
BACKGROUND: Human papillomaviruses (HPV) cause over 500 000 cervical cancers each year, most of which occur in low-resource settings. Human papillomavirus genotyping is important to study natural history and vaccine efficacy. We evaluated TypeSeq, a novel, next-generation, sequencing-based assay that detects 51 HPV genotypes, in 2 large international epidemiologic studies. METHODS: TypeSeq was evaluated in 2804...
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