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Article

AKT1 internal tandem duplications and point mutations are the genetic hallmarks of sclerosing pneumocytoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2020

Yeh Yi-Chen, Ho Hsiang-Ling, Wu Yu-Chung, Pan Chin-Chen, Wang Yu-Chao, Chou Teh-Ying

Abstract excerpt

Sclerosing pneumocytoma is a unique benign neoplasm of the lungs. The molecular alterations in sclerosing pneumocytoma are not well understood. In a previous whole-exome sequencing study, recurrent AKT1 point mutation was observed in about half of the cases of sclerosing pneumocytoma. However, in the remaining half, cancer-related mutations have still not been identified. In this study, we first analyzed the raw...

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Identifiers

PMID: 31527710
DOI: 10.1038/s41379-019-0357-y

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AKT1

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