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Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides

10 Sept 2019

Abstract excerpt

With recent approvals of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the application of these compounds to many other diseases. Our laboratory focuses on developing therapeutic splice modulating antisense oligonucleotides to treat diseases potentially amendable to intervention during pre-mRNA processing, and here we report the use of oligomers to down-regulate integrin...

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PMID: 31506448
DOI: 10.1038/s41598-019-49385-6

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