Article
Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.
Mucosal immunology - 1 Nov 2019
Spalinger Marianne R, Schwarzfischer Marlene, Hering Larissa, Shawki Ali, Sayoc Anica, Santos Alina, Gottier Claudia, Lang Silvia, Bäbler Katharina, Geirnaert Annelies, Lacroix Christophe, Leventhal Gabriel E, Dai Xuezhi, Rawlings David, Chan Andrew A, Rogler Gerhard, McCole Declan F, Scharl Michael
Abstract excerpt
Fecal microbiota transfer (FMT) is a very efficient approach for the treatment of severe and recurring C. difficile infections. However, the beneficial effect of FMT in other disorders such as ulcerative colitis (UC) or Crohn's disease remains unclear. Furthermore, it is currently unknown how disease-associated genetic variants in donors or recipients influence the effect of FMT. We found that bacteria-transfer...
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