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A positive feedback loop of β-catenin/CCR2 axis promotes regorafenib resistance in colorectal cancer

9 Sept 2019

Abstract excerpt

Resistance to molecular targeted therapies is a significant challenge for advanced colorectal cancer (CRC). Understanding the underlying mechanisms and developing effective strategies against regorafenib resistance are highly desired in the clinic. Here, we screened the expression of chemokine receptors and identified CC chemokine receptor 2 (CCR2) as a top upregulated gene in regorafenib-resistant cells. CCR2...

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PMID: 31501414
DOI: 10.1038/s41419-019-1906-5

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