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Article

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila

1 Sept 2019

Abstract excerpt

Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. To determine its role in pathogenesis, we generated mice with mutant Mxra8 alleles: an 8-nucleotide deletion that produces a truncated, soluble form ( Mxra8 Δ8/Δ8 ) and a 97-nucleotide deletion that abolishes Mxra8 expression ( Mxra8 Δ97/Δ97 ). Mxra8...

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Identifiers

PMID: 31484075
DOI: 10.1016/j.celrep.2019.07.105

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