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Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors

20 Aug 2013

Abstract excerpt

Matrix metalloproteinases (MMPs) play important roles in tumor cell proliferation and apoptosis and contribute to tumor growth, angiogenesis, migration, and invasion primarily via extracellular matrix (ECM) degradation and/or the activation of pre-pro-growth factors. Recently, there has been considerable interest in the posttranscriptional regulation of MMPs via microRNAs (miRs). In this review, we highlight the...

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PMID: 23917402
DOI: 10.4161/cbt.25936

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