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Article

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species

1 Jun 2018

Abstract excerpt

Background Recently, Tie2/TEK receptor tyrosine kinase (Tie2 or syn. angiopoietin‐1 receptor) positive nucleus pulposus progenitor cells were detected in human, cattle, and mouse. These cells show remarkable multilineage differentiation capacity and direct correlation with intervertebral disc (IVD) degeneration and are therefore an interesting target for regenerative strategies. Nevertheless, there remains...

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PMID: 31463445
DOI: 10.1002/jsp2.1018

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