Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death

Abstract excerpt

Conflicting data regarding the ability of hydrogen sulfide (H 2 S), which reaches high levels in the large intestine owing to biosynthesis in the intestinal cells and intestinal bacteria, to promote or inhibit colorectal cancer cell proliferation have been reported recently. In the present study, the effect of H 2 S on the proliferation of the human colorectal cancer cell line Caco-2 was examined by using the H 2...

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