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Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome

9 Aug 2019

Abstract excerpt

Abstract Adult stem-cells may serve as the cell-of-origin for cancer, yet their unbiased identification in single cell RNA sequencing data is challenging due to the high dropout rate. In the case of breast, the existence of a bipotent stem-like state is also controversial. Here we apply a marker-free algorithm to scRNA-Seq data from the human mammary epithelium, revealing a high-potency cell-state enriched for an...

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PMID: 31428694
DOI: 10.1038/s42003-019-0554-8

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