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Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation

5 May 2023

Abstract excerpt

BACKGROUND: Tetramates or tetramic acid-containing compounds (TACs) are a group of bioactive natural products featuring a pyrrolidine-2,4-dione ring acknowledged being closed via Dieckmann cyclization. The cariogenic Streptococcus mutans strains bearing a muc biosynthetic gene cluster (BGC) can synthesize mutanocyclin (MUC), a 3-acetylated TAC that can inhibit both leukocyte chemotaxis and filamentous development...

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PMID: 37147735
DOI: 10.1186/s40168-023-01548-4

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