Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm

Abstract excerpt

In most mammals, the male to female sex ratio of offspring is about 50% because half of the sperm contain either the Y chromosome or X chromosome. In mice, the Y chromosome encodes fewer than 700 genes, whereas the X chromosome encodes over 3,000 genes. Although overall gene expression is lower in sperm than in somatic cells, transcription is activated selectively in round spermatids. By regulating the expression...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Share to Reproductive System and Pregnancy