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Article

Proteogenomic landscape of squamous cell lung cancer

8 Aug 2019

Abstract excerpt

How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of which (Inflamed, Redox) comprise 87% of tumors. The Inflamed subtype is enriched with neutrophils,...

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PMID: 31395880
DOI: 10.1038/s41467-019-11452-x

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