MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp

Abstract excerpt

Abstract The myeloid differentiation factor 2 (MD-2)–related lipid-recognition (ML) domain is found in multiple proteins, including MD-2, MD-1, Niemann–Pick disease type C2, and mite major allergen proteins. The significance of ML proteins in antibacterial signal transduction and in lipid metabolism has been well studied. However, their function in host–virus interaction remains poorly understood. In the current...

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