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Article

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

20 Jun 2019

Abstract excerpt

OBJECTIVES: Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9. METHODS: Total IL-18, CXCL9 and...

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PMID: 31326996
DOI: 10.1093/rheumatology/kez282

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