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Article

Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes

6 Jul 2019

Abstract excerpt

The vicious itch–scratch cycle is a cardinal feature of atopic dermatitis (AD), in which IL-13 signaling plays a dominant role. Keratinocytes express two receptors: The heterodimeric IL-4Rα/IL-13Rα1 and IL-13Rα2. The former one transduces a functional IL-13 signal, whereas the latter IL-13Rα2 works as a nonfunctional decoy receptor. To examine whether scratch injury affects the expression of IL-4Rα, IL-13Rα1, and...

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Identifiers

PMID: 31284553
DOI: 10.3390/ijms20133324

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Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in KeratinocytesPMID 31284553Read ↗

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