Intracellular Invasion by Streptococcus pyogenes : Invasins, Host Receptors, and Relevance to Human Disease

Abstract excerpt

ABSTRACT The human oral-nasal mucosa is the primary reservoir for Streptococcus pyogenes infections. Although the most common infection of consequence in temperate climates is pharyngitis, the past 25 years have witnessed a dramatic increase in invasive disease in many regions of the world. Historically, S. pyogenes has been associated with sepsis and fulminate systemic infections, but the mechanism by which...

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