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Article

Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

28 Jun 2019

Abstract excerpt

Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by...

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PMID: 31253784
DOI: 10.1038/s41467-019-10743-7

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