Identification of the key pathways and genes involved in HER2-positive breast cancer with brain metastasis

Abstract excerpt

BACKGROUND: The risk of brain metastasis (BM) in HER2-positive (+) breast cancer (BC) patients is significantly higher than that in HER2-negative (-) BC patients. The high incidence and mortality rate makes it urgent to elucidate the key pathways and genes involved and identify patients who are more at risk of developing BM. MATERIALS AND METHODS: To identify the target genes in HER2+BC patients with BM, we...

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