Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis

6 Jun 2019

Abstract excerpt

In the frame of the VITA mission of the Italian Space Agency (ASI), we addressed the problem of Space osteoporosis by using human blood-derived stem cells (BDSCs) as a suitable osteogenic differentiation model. In particular, we investigated proteomic and epigenetic changes in BDSCs during osteoblastic differentiation induced by rapamycin under microgravity conditions. A decrease in the expression of 4 embryonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone Metabolism and Diseases
Share to Spaceflight effects on biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31171801
DOI: 10.1038/s41598-019-44593-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosisPMID 31171801Read ↗

SCD – Stem Cell Differentiation Toward Osteoblast Onboard the International Space StationSemantic proximity Read ↗

Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cellsSemantic proximity Read ↗

Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and OsteoporosisSemantic proximity Read ↗

Dynamics of Transcription Factors in Three Early Phases of Osteogenic, Adipogenic, and Chondrogenic Differentiation Determining the Fate of Bone Marrow Mesenchymal Stem Cells in RatsSemantic proximity Read ↗

Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration.Semantic proximity Read ↗

Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during AgingSemantic proximity Read ↗

Methyltransferase Setdb1 Promotes Osteoblast Proliferation by Epigenetically Silencing Macrod2 with the Assistance of Atf7ipSemantic proximity Read ↗

Circ_0027885 sponges miR‐203‐3p to regulate RUNX2 expression and alleviates osteoporosis progressionSemantic proximity Read ↗

Osteoblast Differentiation at a GlanceSemantic proximity Read ↗

Early induction of a prechondrogenic population allows efficient generation of stable chondrocytes from human induced pluripotent stem cellsSemantic proximity Read ↗

Exploration of Key Regulatory Factors for Continuous Regulation of Osteogenic Differentiation in Mesenchymal Stem Cells Based on Transcriptomic SequencingSemantic proximity Read ↗

Osteogenic Differentiation in Healthy and Pathological ConditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.