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Regulation of measles virus gene expression by P protein coiled-coil properties

3 May 2019

Abstract excerpt

The polymerase of negative-stranded RNA viruses consists of the large protein (L) and the phosphoprotein (P), the latter serving both as a chaperon and a cofactor for L. We mapped within measles virus (MeV) P the regions responsible for binding and stabilizing L and showed that the coiled-coil multimerization domain (MD) of P is required for gene expression. MeV MD is kinked as a result of the presence of a...

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PMID: 31086822
DOI: 10.1126/sciadv.aaw3702

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