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Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline

3 May 2019

Abstract excerpt

Long non-coding RNA (lncRNA) plays important roles in many diseases, including pulmonary hypertension. The anti-diabetic drug metformin has been discovered to have protective effect on experimental pulmonary artery hypertension (PAH). However, the exact mechanism of metformin on the expression of lncRNA in PAH remains unclear. Here, we applied microarray analysis to examine lncRNA and mRNA expression proflies in...

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PMID: 31060005
DOI: 10.1016/j.biopha.2019.108933

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