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Article

Identification of Genetic Mutations in Cancer: Challenge and Opportunity in the New Era of Targeted Therapy

16 Apr 2019

Abstract excerpt

The introduction of targeted therapy is the biggest success in the treatment of cancer in the past few decades. However, heterogeneous cancer is characterized by diverse molecular alterations as well as multiple clinical profiles. Specific genetic mutations in cancer therapy targets may increase drug sensitivity, or more frequently result in therapeutic resistance. In the past 3 years, several novel targeted...

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PMID: 31058077
DOI: 10.3389/fonc.2019.00263

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