Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis

24 Apr 2019

Abstract excerpt

The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E-selectin on bone marrow endothelium are essential mediators for the engraftment of leukemic stem cells. We hypothesized that non-adhesion of CML-initiating cells to E-selectin on the bone marrow endothelium may lead to superior eradication of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cell Adhesion Molecules Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31018977
DOI: 10.3324/haematol.2018.212365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axisPMID 31018977Read ↗

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistanceSemantic proximity Read ↗

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid LeukaemiaSemantic proximity Read ↗

Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice.Semantic proximity Read ↗

Cadherins, Selectins, and Integrins in CAM-DR in LeukemiaSemantic proximity Read ↗

High CD44 expression identifies rare chemoresistant leukemic cells endowed with enhanced E-Selectin binding in T-ALLSemantic proximity Read ↗

Functional integration of acute myeloid leukemia into the vascular niche.Semantic proximity Read ↗

Selectins in Biology and Human Disease: Opportunity in E-selectin AntagonismSemantic proximity Read ↗

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer ProgressionSemantic proximity Read ↗

Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis.Semantic proximity Read ↗

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt–β-catenin signalingSemantic proximity Read ↗

Not just a marker: CD34 on human hematopoietic stem/progenitor cells dominates vascular selectin binding along with CD44Semantic proximity Read ↗

PSGL-1-Mediated Adhesion of Human Hematopoietic Progenitors to P-Selectin Results in Suppression of HematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.