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Article

Disordered APC/C‐mediated cell cycle progression and IGF1/PI3K/AKT signalling are the potential basis of Sertoli cell‐only syndrome

17 Apr 2019

Abstract excerpt

The cause of Sertoli cell-only syndrome (SCOS), a condition in which only Sertoli cells line the seminiferous tubules in the testis, is unknown. Three microarray data sets were downloaded from public databases and were used to compare SCOS and control group. A total of 291 genes differentially expressed (Log2|FC| ≥ 1 and adjusted p value < 0.05) in SCOS patients. Further 238 genes were significantly...

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PMID: 30995700
DOI: 10.1111/and.13288

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