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Article

TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer.

Journal of the National Cancer Institute - 1 Nov 2019

Mukhopadhyay Utpal K, Oturkar Chetan C, Adams Christina, Wickramasekera Nadi, Bansal Sanjay, Medisetty Rajesh, Miller Austin, Swetzig Wendy M, Silwal-Pandit Laxmi, Børresen-Dale Anne-Lise, Creighton Chad J, Park Jun Hyoung, Konduri Santhi D, Mukhopadhyay Alka, Caradori Alexander, Omilian Angela, Bshara Wiam, Kaipparettu Benny Abraham, Das Gokul M

Abstract excerpt

BACKGROUND: Anti-tumorigenic vs pro-tumorigenic roles of estrogen receptor-beta (ESR2) in breast cancer remain unsettled. We investigated the potential of TP53 status to be a determinant of the bi-faceted role of ESR2 and associated therapeutic implications for triple negative breast cancer (TNBC). METHODS: ESR2-TP53 interaction was analyzed with multiple assays including the in situ proximity ligation assay....

Read the complete abstract on PubMed

Topics

Biomarkers, Tumor
Carcinogenesis
Cell Proliferation
Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Estrogen Receptor beta

Female

Humans

Mutant Proteins

Mutation

Prognosis

Survival Rate

Triple Negative Breast Neoplasms

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 30990221
DOI: 10.1093/jnci/djz051
PMCID: PMC6855950

Genes

ESR2
TP53
BBC3
CDKN1A
TP73

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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