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Article

Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.

Nature microbiology - 1 Jul 2019

Hallez Camille, Li Xiongxiong, Suspène Rodolphe, Thiers Valérie, Bouzidi Mohamed S, M Dorobantu Cristina, Lucansky Vincent, Wain-Hobson Simon, Gaudin Raphaël, Vartanian Jean-Pierre

Abstract excerpt

Numerous human APOBEC3 cytidine deaminases have proven to be, inter alia, host cell restriction factors for retroviruses and hepadnaviruses. Although they can bind to genomic RNA and become encapsidated, they are only catalytically active on single-stranded DNA. As there are many cellular deoxyribonucleases (DNases), we hypothesized that a parallel could be struck between APOBEC3 and DNases. For human hepatitis B...

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Identifiers

PMID: 30936483
DOI: 10.1038/s41564-019-0405-x

Genes

DNASE1

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