Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis

Abstract excerpt

BACKGROUND: Liver fibrosis is often a consequence of chronic liver injury, and has the potential to progress to cirrhosis and liver cancer. Despite being an important human disease, there are currently no approved anti-fibrotic drugs. In this study, we aim to identify the key genes and pathways governing the pathophysiological processes of liver fibrosis, and to screen therapeutic anti-fibrotic agents. METHODS:...

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