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Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

14 Mar 2019

Abstract excerpt

BACKGROUND: The role of n-6 polyunsaturated fatty acids (PUFAs) in ischemic heart disease (IHD) is controversial, and dietary guidelines vary. Observationally, lower saturated fat intake and higher intake of vegetable oils rich in linoleic acid (LA), the main n-6 PUFA, is associated with lower IHD and diabetes; however, randomized controlled trials have not fully corroborated these benefits. We assessed how...

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PMID: 30866921
DOI: 10.1186/s12916-019-1293-x

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