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Article

Role of Microenvironment on the Fate of Disseminating Cancer Stem Cells

21 Feb 2019

Abstract excerpt

Disseminating Cancer Stem Cells (CSCs) initiate growth in specific niches of the host tissues, the cellular and molecular components of which sustain signaling pathways that support their survival, self-renewal dormancy and reactivation. In the metastatic niche, tumor cells may enter in a dormant state to survive and, consequently, the metastasis can remain latent for years. Despite the clinical importance of...

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PMID: 30847298
DOI: 10.3389/fonc.2019.00082

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