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Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells

5 Mar 2019

Abstract excerpt

Abstract Myeloid-derived suppressor cells (MDSCs) are key players in immune evasion, tumor progression and metastasis. MDSCs accumulate under various pathological states and fall into two functionally and phenotypically distinct subsets that have been identified in humans and mice: polymorphonuclear (PMN)-MDSCs and monocytic (M)-MDSCs. As dogs are an excellent model for human tumor development and progression, we...

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PMID: 30837603
DOI: 10.1038/s41598-019-40285-3

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