Article
Mutation clonal burden and allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia and myelodysplastic syndromes.
Bone marrow transplantation - 1 Aug 2019
Hamilton Betty K, Rybicki Lisa, Hirsch Casandra, Przychodzen Bartlomiej, Nazha Aziz, Gerds Aaron T, Hanna Rabi, Kalaycio Matt, Sekeres Mikkael A, Sobecks Ronald, de Lima Marcos, Majhail Navneet S, Maciejewski Jaroslaw
Abstract excerpt
Next generation sequencing (NGS) has become an important tool to inform disease risk for myeloid malignancies, however data remains conflicting regarding the significance of individual mutations. We performed targeted NGS on 112 patients with AML, and 80 with MDS, who underwent allogeneic hematopoietic cell transplantation. The most common mutations in AML were TET2 (14.7%), FLT3 (12.9%), DNMT3A (12.1%), and...
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