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Article

The promising role of PAX1 (aliases: HUP48, OFC2) gene methylation in cancer screening

12 Jan 2019

Abstract excerpt

BACKGROUND: Paired-box gene 1 (PAX1), a member of the PAX family, plays a role in pattern formation during embryogenesis, and might be essential for development of the vertebral column. METHODS: PAX1 is silenced by methylation in several cancers and is considered a tumor suppressor gene. Our previous studies reported PAX1 as hypermethylated in cervical cancer tissues, thereby suggesting it as a potential...

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PMID: 30636379
DOI: 10.1002/mgg3.506

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