Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constant Degradation of the Androgen Receptor by MDM2 Conserves Prostate Cancer Stem Cell Integrity

9 Jan 2019

Abstract excerpt

Abstract Prostate cancer stem cells (CSC) are implicated in tumor initiation, cancer progression, metastasis, and the development of therapeutic-resistant disease. It is well known that the bulk of prostate cancer cells express androgen receptor (AR) and that androgens are required for prostate cancer growth, progression, and emergence of castration-resistant disease. In contrast, the small subpopulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30626627
DOI: 10.1158/0008-5472.can-18-1753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constant Degradation of the Androgen Receptor by MDM2 Conserves Prostate Cancer Stem Cell IntegrityPMID 30626627Read ↗

Prostate cancer stem cell dynamics in the evolution of drug resistanceSemantic proximity Read ↗

Androgen receptor and prostate cancer stem cells: biological mechanisms and clinical implications.Semantic proximity Read ↗

Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemnessSemantic proximity Read ↗

The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the FutureSemantic proximity Read ↗

Role of prostate cancer stem-like cells in the development of antiandrogen resistanceSemantic proximity Read ↗

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cellsSemantic proximity Read ↗

Prostate cancer stem cells: a new target for therapy.Semantic proximity Read ↗

Cancer Stem Cells in Prostate Cancer: Implications for Targeted Therapy.Semantic proximity Read ↗

Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease ProgressionSemantic proximity Read ↗

Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease ProgressionSemantic proximity Read ↗

Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient SurvivalSemantic proximity Read ↗

Therapeutic implications of cancer stem cells in prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.