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Article

Bromodomain protein inhibition: a novel therapeutic strategy in rheumatic diseases

1 Nov 2018

Abstract excerpt

The reading of acetylation marks on histones by bromodomain (BRD) proteins is a key event in transcriptional activation. Small molecule inhibitors targeting bromodomain and extra-terminal (BET) proteins compete for binding to acetylated histones. They have strong anti-inflammatory properties and exhibit encouraging effects in different cell types in vitro and in animal models resembling rheumatic diseases in...

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PMID: 30564450
DOI: 10.1136/rmdopen-2018-000744

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