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Article

Functionality and cross-regulation of the four SprG/SprF type I toxin–antitoxin systems in Staphylococcus aureus

4 Dec 2018

Abstract excerpt

Toxin-antitoxin (TA) systems are ubiquitous among bacteria, frequently expressed in multiple copies, and important for functions such as antibiotic resistance and persistence. Type I TA systems are composed of a stable toxic peptide whose expression is repressed by an unstable RNA antitoxin. Here, we investigated the functionalities, regulation, and possible cross-talk between three core genome copies of the...

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PMID: 30551143
DOI: 10.1093/nar/gky1256

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